CVS-1123
CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies[1][2]
Product Specifications
CAS Number
151275-19-3
UNSPSC
12352005
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C([C@H](CC(OC)=O)NC(C(CCC)CCC)=O)N1[C@H](C(N[C@H](C=O)CCCNC(N)=N)=O)CCC1
Molecular Formula
C24H42N6O6
Molecular Weight
510.63
References & Citations
[1]Rebello SS, et al. CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury. J Cardiovasc Pharmacol. 1997 Feb;29 (2) :240-9.|[2]Cousins GR, et al. Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog. Circulation. 1996 Oct 1;94 (7) :1705-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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