S-18326
S-18326 is an orally active direct thrombin inhibitor. S-18326 inhibits thrombus formation by reversibly and with high affinity binding to the active site of thrombin, directly preventing the conversion of fibrinogen to fibrin. S-18326 effectively prolongs various clotting times in human plasma. S-18326 has demonstrated antithrombotic efficacy in multiple animal models without causing thrombocytopenia. S-18326 can be used in research on thromboembolic diseases[1].
Product Specifications
CAS Number
167843-21-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N(C1CCCC1)CC(N[C@@H](CCCNC(N)=N)B(O)O)=O)[C@H](NC(C)=O)CC2=CC=CC=C2
Molecular Formula
C23H37BN6O5
Molecular Weight
488.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
Phase 1
Frequently Asked Questions
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