KW-2170 (hydrochloride)
KW-2170 hydrochloride is an alkylating agent and topoisomerase II inhibitor. KW-2170 hydrochloride stabilizes the topoisomerase II-DNA complex, causing DNA double-strand breaks, thereby preventing DNA replication and transcription, and ultimately leading to the death of tumor cells. KW-2170 hydrochloride exhibits potent and broad-spectrum anti-tumor activity in various mouse and human tumor models. KW-2170 hydrochloride can be used in the research of solid tumors[1][2].
Product Specifications
CAS Number
207862-44-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1C2=C(C(O)=CC=C2O)N(N=C3CNCCO)C4=C3C=CC(NCCCN)=C14.Cl.Cl
Molecular Formula
C20H25Cl2N5O4
Molecular Weight
470.35
References & Citations
[1]Ashizawa T, et al. Antitumor activity of KW-2170, a novel pyrazoloacridone derivative. Anticancer Drugs. 1998 Mar;9 (3) :263-71. |[2]Verschraegen CF. KW-2170 (Kyowa Hakko Kogyo) . IDrugs. 2002 Oct;5 (10) :1000-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo II
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