ZD-2767

ZD-2767 is an antibody-directed enzyme prodrug therapy (ADEPT) agent. ZD-2767 is composed of the prodrug ZD2767P, carboxypeptidase G2 (CPG2), and the active drug ZD2767D. ZD-2767 achieves tumor-targeted drug delivery through an innovative ADEPT strategy, triggering apoptosis of cancer cells by causing irreparable DNA damage. ZD-2767 can be used for cancer research[1].

Product Specifications

CAS Number

156079-88-8

UNSPSC

12352005

Target

Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(OC1=CC=C(N(CCI)CCI)C=C1)=O

Molecular Formula

C16H20I2N2O6

Molecular Weight

590.15

References & Citations

[1]Monks NR, et al. Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue. Br J Cancer. 2001 Sep 1;85 (5) :764-71.