CGP-49823

CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor) . CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research[1][2].

Product Specifications

CAS Number

150705-88-7

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5

Molecular Formula

C31H33N3O

Molecular Weight

463.61

References & Citations

[1]File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58 (3) :747-52.|[2]Pozza MF, et al. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342 (2-3) :203-8.