CGP-49823
CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor) . CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research[1][2].
Product Specifications
CAS Number
150705-88-7
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5
Molecular Formula
C31H33N3O
Molecular Weight
463.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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