Axitirome
Axitirome (CGS 26214) is a potent, liverselective TRβ receptor agonist and thyromimetic agent. Axitirome has demonstrated cholesterol-lowering activity[1].
Product Specifications
CAS Number
156740-57-7
Product Name Alternative
CGS 26214
UNSPSC
12352005
Hazard Statement
H302-H372-H411
Target
Thyroid Hormone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(OCC)C(NC1=CC(C)=C(OC2=CC=C(O)C(C(C3=CC=C(F)C=C3)O)=C2)C(C)=C1)=O
Molecular Formula
C25H24FNO6
Molecular Weight
453.46
Precautions
P260-P264-P273-P391-P501
References & Citations
[1]Wu R, et al. Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model. PNAS Nexus. 2023 Aug 29;2 (8) :pgad252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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