SB-201993
SB-201993 is a selective leukotriene B₄ (LTB4) receptor antagonist with a Ki=7.6 nM for LTB4 receptors on human inflammatory cells. SB-201993 inhibits calcium mobilization in inflammatory cells and 5-lipoxygenase activity, exerting anti-inflammatory effects. SB-201993 is promising for research of inflammatory diseases (e.g., dermatitis, arthritis) [1].
Product Specifications
CAS Number
150399-22-7
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(O)C1=CC=CC(CSCC2=NC(/C=C/C(O)=O)=C(OCCCCCCCCC3=CC=C(OC)C=C3)C=C2)=C1
Molecular Formula
C32H37NO6S
Molecular Weight
563.70
References & Citations
[1]Sarau HM, et al. In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity. Prostaglandins Leukot Essent Fatty Acids. 1999 Jul;61 (1) :55-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTB4
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