MKC-963
MKC-963 is an orally active and potent inhibitor targeting platelet aggregation-related pathways. MKC-963 exerts antithrombotic activity by inhibiting platelet aggregation, and can also induce autoinduction, i.e., upregulating the mRNA expression and activity of CYP3A4 enzyme to accelerate its own metabolism in vivo. MKC-963 is promising for research of platelet aggregation-related diseases (e.g., thrombosis) [1].
Product Specifications
CAS Number
149549-14-4
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
C[C@@H](NC1=NN=C(C2=CC=CC=C2)C3=C1C=CC=C3)C4CCCCC4
Molecular Formula
C22H25N3
Molecular Weight
331.45
References & Citations
[1]Shimizu T, et al. Autoinduction of MKC-963 [ (R) -1- (1-cyclohexylethylamino) -4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes[J]. Drug metabolism and disposition, 2006, 34 (6) : 950-954.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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