FK 633
FK 633 (FR-144633) is a fibrinogen inhibitor and peptide mimetic GPIIbIIa receptor antagonist. FK 633 has anti-platelet and anti-thrombotic effects. FK 633 inhibits ADP-, collagen-, thrombin-, and PAF-induced platelet aggregation with IC50 values of 103, 87, 98, and 239 nM, respectively[1][2].
Product Specifications
CAS Number
147865-49-4
Product Name Alternative
FR-144633
UNSPSC
12352005
Target
Integrin; Thrombin
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(CCCOC1=CC=C(C(N)=N)C=C1)=O)=O
Molecular Formula
C20H28N4O7
Molecular Weight
436.46
References & Citations
[1]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50. |[2]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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