BTS-67582

BTS-67582 is an orally active nonsulfonylurea insulinotropic agent and potassium channel blocker. BTS-67582 affects the K+ ATP channel in the islet cell but at a different binding site than the sulfonylureas. BTS-67582 is an antidiabetic agent[1][2].

Product Specifications

CAS Number

161748-40-9

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology; Metabolic Disease

Smiles

N=C(NC1=CC=CC=C1N2CCOCC2)N(C)C.O=C(O)/C=C/C(O)=O

Molecular Formula

C17H24N4O5

Molecular Weight

364.40

References & Citations

[1]Skillman CA, Raskin P. A double-masked placebo-controlled trial assessing effects of various doses of BTS 67,582, a novel insulinotropic agent, on fasting hyperglycemia in NIDDM patients. Diabetes Care. 1997 Apr;20 (4) :591-6. 7,582, a Novel Insulinotropic Agent, on Fasting Hyperglycemia in NIDDM Patients|[2]Louchami K, et al. Effect of 1,1-dimethyl-2-[2-morpholinophenyl]guanidine fumarate on pancreatic islet function. Eur J Pharmacol. 1998 Jul 10;352 (2-3) :289-97.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2