E-6700
E-6700 is an inhibitor of 5-LO and TXA2 synthetase, with IC50s of 16.3 μM and 0.026 μM respectively. E-6700 inhibits LTB4 and TXB2 production. E-6700 can be used for antiinflammatory research[1].
Product Specifications
CAS Number
144562-61-8
UNSPSC
12352005
Target
Lipoxygenase; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(O)/C(CCCCCC1=CN=CC=C1)=C/C2=C(C)C(C(OC)=C(C)C2=O)=O
Molecular Formula
C22H25NO5
Molecular Weight
383.44
References & Citations
[1]Hibi S, et al. Structure-activity relationships of (E) -3- (1,4-benzoquinonyl) -2-[ (3-pyridyl) -alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39 (16) :3148-57.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-LOX; TXA2/TP
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