E-6700

E-6700 is an inhibitor of 5-LO and TXA2 synthetase, with IC50s of 16.3 μM and 0.026 μM respectively. E-6700 inhibits LTB4 and TXB2 production. E-6700 can be used for antiinflammatory research[1].

Product Specifications

CAS Number

[144562-61-8]

UNSPSC

12352005

Target

Lipoxygenase; Prostaglandin Receptor

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(O)/C(CCCCCC1=CN=CC=C1)=C/C2=C(C)C(C(OC)=C(C)C2=O)=O

Molecular Formula

C22H25NO5

Molecular Weight

383.44

References & Citations

[1]Hibi S, et al. Structure-activity relationships of (E) -3- (1,4-benzoquinonyl) -2-[ (3-pyridyl) -alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39 (16) :3148-57.