SDZ-FOX-988

SDZ-FOX-988 (FOX-988) is an orally active antidiabetic agent. SDZ-FOX-988 sequesters mitochondrial coenzyme A to inhibit carnitine palmitoyltransferase II. SDZ-FOX-988 induces mitochondrial injury. SDZ-FOX-988 causes a decrease in serum β-hydroxybutyrate or glucose. SDZ-FOX-988 can be used in the research of type 2 diabetes[1][2].

Product Specifications

CAS Number

139681-18-8

Product Name Alternative

FOX-988

UNSPSC

12352005

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(C(C)(C)C)C1=CC=C(/C(OC(C2=CC=C(C(C(C)(C)C)=O)C=C2)=O)=N\OC)C=C1

Molecular Formula

C25H29NO5

Molecular Weight

423.50

References & Citations

[1]Lau DT, et al. The effect of the fat content of food on the pharmacokinetics and pharmacodynamics of SDZ FOX 988, an antidiabetic agent, in the dog. Biopharm Drug Dispos. 1995 Mar;16 (2) :137-50. |[2]Vickers AE, et al. Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. Toxicol In Vitro. 2006 Oct;20 (7) :1173-82.