ME 3407
ME-3407 (EF-4040) is a H+-K+-ATPase redistribution disruptor and myosin light chain kinase (MLCK) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H+-K+-ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer[1].
Product Specifications
CAS Number
133903-90-9
Product Name Alternative
EF-4040
UNSPSC
12352005
Target
Myosin; Na+/K+ ATPase; PKA
Related Pathways
Cytoskeleton; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(OCCCC)CS(C1=NC2=CC=CN=C2S1)=O
Molecular Formula
C12H14N2O3S2
Molecular Weight
298.38
References & Citations
[1]Urushidani T, et al. ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H (+) -K (+) -ATPase. Am J Physiol. 1997 May;272 (5 Pt 1) :G1122-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MLCK
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