CI-990

CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis) [1][2].

Product Specifications

CAS Number

[122536-20-3]

Product Name Alternative

PD-131112

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@@H](NC([C@@H](N)C)=O)CC4)=N3)C1=O)O

Molecular Formula

C19H22FN5O4

Molecular Weight

403.41

References & Citations

[1]Cohen MA, et al. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J Antimicrob Chemother. 1998 Jun;41 (6) :605-14.|[2]Cohen MA, et al. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995 Sep;39 (9) :2123-7.