CI-990
CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis) [1][2].
Product Specifications
CAS Number
122536-20-3
Product Name Alternative
PD-131112
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@@H](NC([C@@H](N)C)=O)CC4)=N3)C1=O)O
Molecular Formula
C19H22FN5O4
Molecular Weight
403.41
References & Citations
[1]Cohen MA, et al. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J Antimicrob Chemother. 1998 Jun;41 (6) :605-14.|[2]Cohen MA, et al. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995 Sep;39 (9) :2123-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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