KRN-2391

KRN-2391 is a KATP channel opener with NO donor properties. KRN-2391 exerts dual inhibitory effects on overactive bladder (OAB) by activating KATP channels (causing cellular hyperpolarization and bladder smooth muscle relaxation) and releasing NO (enhancing relaxation via cGMP pathways) . KRN-2391 is promising for research of OAB[1].

Product Specifications

CAS Number

[134431-49-5]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=[N+](OCC/N=C(C1=CC=CN=C1)/NC#N)[O-].CS(=O)(O)=O

Molecular Formula

C10H13N5O6S

Molecular Weight

331.31

References & Citations

[1]Kamiyama Y, et al. Inhibitory effects of nicorandil, a K ATP channel opener and a nitric oxide donor, on overactive bladder in animal models. BJU Int. 2008 Feb;101 (3) :360-5.