KRN-2391
KRN-2391 is a KATP channel opener with NO donor properties. KRN-2391 exerts dual inhibitory effects on overactive bladder (OAB) by activating KATP channels (causing cellular hyperpolarization and bladder smooth muscle relaxation) and releasing NO (enhancing relaxation via cGMP pathways) . KRN-2391 is promising for research of OAB[1].
Product Specifications
CAS Number
134431-49-5
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=[N+](OCC/N=C(C1=CC=CN=C1)/NC#N)[O-].CS(=O)(O)=O
Molecular Formula
C10H13N5O6S
Molecular Weight
331.31
References & Citations
[1]Kamiyama Y, et al. Inhibitory effects of nicorandil, a K ATP channel opener and a nitric oxide donor, on overactive bladder in animal models. BJU Int. 2008 Feb;101 (3) :360-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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