WY-50295

WY-50295 is an orally active and selective 5-lipoxygenase inhibitor. WY-5029 inhibits LTB4 formation in rat whole blood leukocytes (IC50: 40 μM and oral ED50: 18 mg/kg) . WY-50295 can be used in the study of asthma and other leukotriene-dependent diseases[1].

Product Specifications

CAS Number

[123016-21-7]

UNSPSC

12352005

Target

Lipoxygenase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC([C@@H](C)C1=CC=C2C(C=CC(OCC3=NC(C=CC=C4)=C4C=C3)=C2)=C1)=O

Molecular Formula

C23H19NO3

Molecular Weight

357.40

References & Citations

[1]Carlson R, et al. WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60 (1) :31-41.|[2]Grimes D, et al. WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity. Eur J Pharmacol. 1993 May 19;236 (2) :217-28.