CI-959
CI-959 is an inhibitor of inflammatory cell activation. CI-959 exhibits anti-inflammatory and anti-allergic activities. CI-959 can inhibit the production of reactive oxygen species by neutrophils, as well as neutrophil adhesion, respiratory burst, and histamine release from mast cells. CI-959 can also inhibit the release of inflammatory mediators such as histamine, leukotrienes, and thromboxane from guinea-pig and human lung tissues, and effectively suppress anti-IgE-induced contractions of human bronchial smooth muscle. CI-959 can be used in the research of inflammatory and allergic diseases, such as asthma[1][2][3].
Product Specifications
CAS Number
[104795-68-8]
UNSPSC
12352005
Target
Histamine Receptor; Reactive Oxygen Species (ROS)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Endocrinology; Inflammation/Immunology
Smiles
COC1=CC=C2C(C(OC(C)C)=C(C(NC3=NN=NN3)=O)S2)=C1.[Na]
Molecular Formula
C14H15N5NaO3S
Molecular Weight
356.36
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19108/
Scientific Category
Reference compound1
Clinical Information
Phase 1
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