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MCI-727 (free base)

MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases[1][2].

Product Specifications

CAS Number

132197-26-3

UNSPSC

12352005

Target

Secretin Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Smiles

CN1CCN(C/C(C2=CC=C(CCC3=CC=CC=C3)C=C2)=N\O)CC1

Molecular Formula

C21H27N3O

Molecular Weight

337.46

References & Citations

[1]Kawamura M, et al. Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats. Jpn J Pharmacol. 1991 Aug;56 (4) :513-22.|[2]Tachibana I, et al. Effects of MCI-727 on pancreatic exocrine secretion and acute pancreatitis in two experimental rat models. Pancreas. 1996 Mar;12 (2) :165-72.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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