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IT 066 (hydrochloride)

IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases[1][2].

Product Specifications

CAS Number

[126463-66-9]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C1C(C(N)=C1NC/C=C\COC2=NC=CC(CN3CCCCC3)=C2)=O.Cl

Molecular Formula

C19H25ClN4O3

Molecular Weight

392.88

References & Citations

[1]Naito Y, et al. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294 (1) :47-54.|[2]Isobe Y, et al. Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats. J Pharmacol Exp Ther. 1990 Dec;255 (3) :1078-82.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19105A/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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