FK 409

FK 409 is a NO donor that can penetrate cell membranes. FK 409 has a vasodilatory effect on bovine retinal arteries. FK 409 alleviates acute-phase inflammation, induces HSP, and mitigates liver transplantation injury in a rat model of orthotopic liver transplantation. FK 409 can be used in research on cardiovascular diseases and liver transplant rejection and inflammatory immune system disorders[1][2].

Product Specifications

CAS Number

[92454-60-9]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

HSP; NO Synthase

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Smiles

CC([N+]([O-])=O)/C(CC)=C/C(C(N)=O)=N/O

Molecular Formula

C8H13N3O4

Molecular Weight

215.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Man K, et al. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg. 2004 Jul;240 (1) :159-68.|[2]Sugimoto K, et al. [Vasodilatory action of FK 409 on bovine retinal arteries--analysis by a microvessel perfusion system]. Nippon Ganka Gakkai Zasshi. 2002 Jun;106 (6) :338-42. Japanese.