SKF-105809
SKF-105809 is a dual-action inhibitor of lipoxygenase and COX. SKF-105809 inhibits edema and inflammatory cell infiltration in mouse models of ear, paw, and peritoneum inflammation. SKF-105809 inhibits the production of relevant acute-phase reactive proteins in a mouse model of arthritis. SKF-105809 exhibits analgesic activity in a mouse abdominal contraction test and inhibits ulceration. SKF-105809 can be used in research on inflammatory and immune system diseases such as peritonitis and arthritis[1].
Product Specifications
CAS Number
[122454-69-7]
UNSPSC
12352005
Target
COX; Lipoxygenase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=S(C)C1=CC=C(C2=C(C3=CC=NC=C3)N(CCC4)C4=N2)C=C1
Molecular Formula
C18H17N3OS
Molecular Weight
323.41
References & Citations
[1]Hanna N, et al. Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. Drugs Exp Clin Res.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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