SC-45662

SC-45662 is a 5-lipoxygenase inhibitor. SC-45662 inhibits the response of monocytes to phytohemagglutinin (PHA) . SC-45662 inhibits superoxide production in neutrophils. SC-45662 slows early changes in lung mechanics and pulmonary hypertension in a sheep model of impaired lung function. SC-45662 can be used in research on diseases of the immune system, respiratory system, etc[1][2][3].

Product Specifications

CAS Number

135133-84-5

UNSPSC

12352005

Target

Lipoxygenase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(O)CO[C@@H](C)[C@H](SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)C

Molecular Formula

C20H32O4S

Molecular Weight

368.53

References & Citations

[1]Weir MR, et al. The immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor (SC-45662) . Transplantation. 1991 Dec;52 (6) :1053-7.|[2]Kocan GP, et al. Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionyl-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation. Biochem Pharmacol. 1994 Mar 15;47 (6) :1029-37. |[3]Kuratomi Y, et al. Effect of a 5-lipoxygenase inhibitor on endotoxin-induced pulmonary dysfunction in awake sheep. J Appl Physiol (1985) . 1993 Feb;74 (2) :596-605.