DS 4574
DS 4574 is an orally active peptidoleukotriene receptor antagonist and mast cell stabilizer. DS 4574 has antiulcer, gastroprotective and antisecretory effects. DS 4574 inhibits various types of experimental asthma models. DS 4574 protects rats from endotoxin-induced intestinal injury[1][2][3].
Product Specifications
CAS Number
[118314-35-5]
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(N=C3SC(CCC4CCCCC4)=NN13)N=NN2
Molecular Formula
C13H16N6OS
Molecular Weight
304.37
References & Citations
[1]Tabuchi Y, et al. Protective effect of DS-4574, a peptidoleukotriene receptor antagonist, against endotoxin-induced intestinal injury in rats. Eur J Pharmacol. 1995 Feb 6;273 (3) :281-4.|[2]Yamashika Y, et al. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41 (1-2) :17-20.|[3]Tabuchi Y, et al. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60 (4) :335-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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