DS 4574

DS 4574 is an orally active peptidoleukotriene receptor antagonist and mast cell stabilizer. DS 4574 has antiulcer, gastroprotective and antisecretory effects. DS 4574 inhibits various types of experimental asthma models. DS 4574 protects rats from endotoxin-induced intestinal injury[1][2][3].

Product Specifications

CAS Number

[118314-35-5]

UNSPSC

12352005

Target

Leukotriene Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C1C2=C(N=C3SC(CCC4CCCCC4)=NN13)N=NN2

Molecular Formula

C13H16N6OS

Molecular Weight

304.37

References & Citations

[1]Tabuchi Y, et al. Protective effect of DS-4574, a peptidoleukotriene receptor antagonist, against endotoxin-induced intestinal injury in rats. Eur J Pharmacol. 1995 Feb 6;273 (3) :281-4.|[2]Yamashika Y, et al. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41 (1-2) :17-20.|[3]Tabuchi Y, et al. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60 (4) :335-40.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2