BRL-52656
BRL-52656 is a blood-brain barrier (BBB) -penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) [1][2].
Product Specifications
CAS Number
[115642-84-7]
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
FC(F)(F)C(C=C1)=CC=C1CC(N(CCCC2)[C@@H]2CN3CCCC3)=O.Cl
Molecular Formula
C19H26ClF3N2O
Molecular Weight
390.87
References & Citations
[1]Brooks DP, et al. Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther. 1993 Jul;266 (1) :164-71.|[2]Sako MO, et al. Filtering the Signal: Kappa Opioid Receptors in the Kidney. Function (Oxf) . 2025 Sep 15;6 (5) :zqaf042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
κ Opioid Receptor/KOR
Curated Selection
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