Pyrazine diazohydroxide (sodium)
Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia[1][2].
Product Specifications
CAS Number
[103829-46-5]
Product Name Alternative
NSC-361456 (sodium)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=NNC1=NC=CN=C1.[Na]
Molecular Formula
C4H4N4NaO
Molecular Weight
147.09
References & Citations
[1]Harrison SD Jr, et al. Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol. 1990;25 (6) :425-9.|[2]Vogelzang NJ, et al. Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer. Clin Cancer Res. 1998 Apr;4 (4) :929-34.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19045/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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