Merbarone (Standard)

Merbarone (Standard) is the analytical standard of Merbarone. This product is intended for research and analytical applications. Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent[1][2][4].

Product Specifications

CAS Number

[97534-21-9]

UNSPSC

12352100

Target

Reference Standards; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

O=C(C(C(N1)=O)C(NC1=S)=O)NC2=CC=CC=C2

Molecular Formula

C11H9N3O3S

Molecular Weight

263.27

References & Citations

[1]Fortune JM, et, al. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998 Jul 10;273 (28) :17643-50.|[2]Brewer AD, et, al. 5- (N-phenylcarboxamido) -2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent. Biochem Pharmacol. 1985 Jun 1;34 (11) :2047-50.|[3]Cooney DA, et, al. Initial mechanistic studies with merbarone (NSC 336628) . Biochem Pharmacol. 1985 Sep 15;34 (18) :3395-8.|[4]Chen M, et, al. Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res. 1995 Apr 1;55 (7) :1509-16.