FK-664
FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure[1][2].
Product Specifications
CAS Number
[94936-90-0]
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O=C1N(C)/C(C=C(N1CC)C2=CC(OC)=C(OC)C=C2)=N/C3=C(C)C=C(C)C=C3C
Molecular Formula
C24H29N3O3
Molecular Weight
407.51
References & Citations
[1]Kodama I, et al. Electrophysiological effects of FK664, a new cardiotonic agent, on preparations from guinea pig ventricle and from rabbit sino-atrial node. Cardiovasc Res. 1989 May;23 (5) :369-77.|[2]Sudo Y, et al. The effect of FK664, a new cardiovascular drug, on systemic capacitance vessels in anesthetized dogs. Life Sci. 1992;51 (25) :PL261-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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