FK-664

FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure[1][2].

Product Specifications

CAS Number

[94936-90-0]

UNSPSC

12352005

Target

Leukotriene Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=C1N(C)/C(C=C(N1CC)C2=CC(OC)=C(OC)C=C2)=N/C3=C(C)C=C(C)C=C3C

Molecular Formula

C24H29N3O3

Molecular Weight

407.51

References & Citations

[1]Kodama I, et al. Electrophysiological effects of FK664, a new cardiotonic agent, on preparations from guinea pig ventricle and from rabbit sino-atrial node. Cardiovasc Res. 1989 May;23 (5) :369-77.|[2]Sudo Y, et al. The effect of FK664, a new cardiovascular drug, on systemic capacitance vessels in anesthetized dogs. Life Sci. 1992;51 (25) :PL261-5.