FIT-039 (Standard)
FIT-039 (Standard) is the analytical standard of FIT-039. This product is intended for research and analytical applications. FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
Product Specifications
UNSPSC
12352100
Target
CDK; CMV; DNA/RNA Synthesis; HSV; Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Smiles
FC1=CC(NC(C2=CC=NC=C2)=S)=C(N3CCCCC3)C=C1
Molecular Formula
C17H18FN3S
Molecular Weight
315.41
References & Citations
[1]Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124 (8) :3479-88.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18944R/
Scientific Category
Reference Standards
CAS Number
[1113044-49-7]
Available Sizes
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