R-03201195
R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis[1].
Product Specifications
CAS Number
249936-55-8
UNSPSC
12352005
Target
Interleukin Related; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC[C@H](O)COC1=CC=CC(C(C2=C(N)N(C3=CC=C(F)C=C3)N=C2)=O)=C1
Molecular Formula
C19H18FN3O4
Molecular Weight
371.36
References & Citations
[1]Goldstein DM, et al. Discovery of S-[5-amino-1- (4-fluorophenyl) -1H-pyrazol-4-yl]-[3- (2,3-dihydroxypropoxy) phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase. J Med Chem. 2006 Mar 9;49 (5) :1562-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; p38 MAPK
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