L-NMMA (acetate) (Standard)

L-NMMA (acetate) (Standard) is the analytical standard of L-NMMA (acetate) . This product is intended for research and analytical applications. L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

Product Specifications

CAS Number

[53308-83-1]

UNSPSC

12352100

Target

Endogenous Metabolite; NO Synthase; Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease; Cancer

Smiles

N[C@@H](CCCNC(NC)=N)C(O)=O.O=C(C)O

Molecular Formula

C9H20N4O4

Molecular Weight

248.28

References & Citations

[1]Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269 (42) :26083-91.|[2]Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103 (4) :1970-2.|[3]Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261 (1 Pt 2) :H46-52.