Voxelotor-d6
Voxelotor-d6 (GBT 440-d6) is deuterium labeled Voxelotor. Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment[1].
Product Specifications
CAS Number
2170187-39-8
Product Name Alternative
GBT 440-d6
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=CC(C(O)=CC=C1)=C1OCC2=C(C3=CC=NN3C(C([2H])([2H])[2H])C([2H])([2H])[2H])N=CC=C2
Molecular Formula
C19H13D6N3O3
Molecular Weight
343.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Oksenberg D, et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br J Haematol. 2016 Oct;175 (1) :141-53.|[3]Metcalf B, Chuang C, Dufu K, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017;8 (3) :321-326.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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