Voxelotor (Standard)
Voxelotor (Standard) is the analytical standard of Voxelotor. This product is intended for research and analytical applications. Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment[1].
Product Specifications
CAS Number
1446321-46-5
UNSPSC
12352100
Target
Others; Reference Standards
Related Pathways
Others
Field of Research
Cardiovascular Disease
Smiles
OC1=CC=CC(OCC2=C(C3=CC=NN3C(C)C)N=CC=C2)=C1C=O
Molecular Formula
C19H19N3O3
Molecular Weight
337.37
References & Citations
[1]Oksenberg D, et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br J Haematol. 2016 Oct;175 (1) :141-53.|[2]Metcalf B, Chuang C, Dufu K, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017;8 (3) :321-326.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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