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DZ2002 (Standard)

DZ2002 (Standard) is the analytical standard of DZ2002. This product is intended for research and analytical applications. DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis[1][2].

Product Specifications

CAS Number

33231-14-0

UNSPSC

12352100

Target

Akt; Antibiotic; Bacterial; ERK; MEK; NF-κB; PI3K; Reference Standards; STAT

Related Pathways

Anti-infection; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

OC(C(OC)=O)CCN1C(N=CN=C2N)=C2N=C1

Molecular Formula

C10H13N5O3

Molecular Weight

251.25

References & Citations

[1]Wu QL, et al. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J Pharmacol Exp Ther. 2005 May;313 (2) :705-11. |[2]Zhang Z, et al. DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. Arthritis Res Ther. 2019 Dec 16;21 (1) :290.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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