Diclofensine-d3 (hydrochloride)

Diclofensine-d3 hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

Product Specifications

CAS Number

[1794780-41-8]

UNSPSC

12352005

Target

Dopamine Transporter; Isotope-Labeled Compounds

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C(C2)=C1)C(C3=CC(Cl)=C(C=C3)Cl)CN2C([2H])([2H])[2H].Cl

Molecular Formula

C17H15D3Cl3NO

Molecular Weight

361.71

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44 (5) :1615-22.|[3]Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39 (5) :582-5.|[4]Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42 (21) :2161-9.