Diclofensine-d3 (hydrochloride)
Diclofensine-d3 hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
Product Specifications
CAS Number
1794780-41-8
UNSPSC
12352005
Target
Dopamine Transporter; Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C(C2)=C1)C(C3=CC(Cl)=C(C=C3)Cl)CN2C([2H])([2H])[2H].Cl
Molecular Formula
C17H15D3Cl3NO
Molecular Weight
361.71
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44 (5) :1615-22.|[3]Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39 (5) :582-5.|[4]Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42 (21) :2161-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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