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OTX-2002

OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB) . OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.

Product Specifications

UNSPSC

12352208

Target

MRNA

Related Pathways

Others

Field of Research

Cancer

Smiles

[OTX-2002]

References & Citations

[1]Senapedis W, Gallagher KM, Figueroa E, et al. Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models. Nat Commun. 2024;15 (1) :7875.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Frequently Asked Questions

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