OTX-2002
OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB) . OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.
Product Specifications
UNSPSC
12352208
Target
MRNA
Related Pathways
Others
Field of Research
Cancer
Smiles
[OTX-2002]
References & Citations
[1]Senapedis W, Gallagher KM, Figueroa E, et al. Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models. Nat Commun. 2024;15 (1) :7875.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
