DOV-102,677

DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression[1].

Product Specifications

CAS Number

[410074-75-8]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Transporter

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

ClC1=CC=C([C@@]23CNC[C@]2([H])C3)C=C1Cl

Molecular Formula

C11H11Cl2N

Molecular Weight

228.12

References & Citations

[1] Shao L, et al. Discovery of N-methyl-1- (1-phenylcyclohexyl) methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21 (5) :1438-41|[2]Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633 (1-3) :55-61