SB 242235 (Standard)
SB 242235 (Standard) is the analytical standard of SB 242235. This product is intended for research and analytical applications. SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0 μM in primary human chondrocytes[1].
Product Specifications
CAS Number
193746-75-7
UNSPSC
12352100
Target
Autophagy; p38 MAPK; Reference Standards
Related Pathways
Autophagy; MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
COC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1
Molecular Formula
C19H20FN5O
Molecular Weight
353.39
References & Citations
[1]Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8 (6) : p. 434-43.|[2]Kim AL , et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol. 2005 Jun;124 (6) :1318-25.|[3]Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32 (3) : p. 221-33.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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