Purvalanol A (Standard)

Purvalanol A (Standard) is the analytical standard of Purvalanol A. This product is intended for research and analytical applications. Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.

Product Specifications

CAS Number

[212844-53-6]

UNSPSC

12352100

Target

Apoptosis; Autophagy; CDK; Reference Standards

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

CC([C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO)C

Molecular Formula

C19H25ClN6O

Molecular Weight

388.89

References & Citations

[1]Gray NS, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281 (5376) :533-8.|[2]Bain J, et al. The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371 (Pt 1) :199-204.|[3]Villerbu N, et al. Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer. 2002 Feb 20;97 (6) :761-9.