Leupeptin (hemisulfate) (Standard)

Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate) . This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[103476-89-7]

UNSPSC

12352211

Target

Cathepsin; Reference Standards; Ser/Thr Protease; Virus Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4]

Molecular Formula

C20H38N6O4.1/2H2SO4

Molecular Weight

475.59

References & Citations

[1]Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12 (5) :e0222021.|[2]Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7 (6) :629-42.|[3]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo) . 1969 Nov;22 (11) :558-68.|[4]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo) . 1969 Nov;22 (11) :558-68.