TC-6683
TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder[1][2].
Product Specifications
CAS Number
1025007-04-8
Product Name Alternative
AZD1446
UNSPSC
12352005
Hazard Statement
H302
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1CC2CNCC2C1)C3=CC=C(Cl)O3
Molecular Formula
C11H13ClN2O2
Molecular Weight
240.69
Precautions
P264-P270-P330-P501
References & Citations
[1]Mazurov AA, et al. Discovery of 3- (5-chloro-2-furoyl) -3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. J Med Chem. 2012 Nov 8;55 (21) :9181-94.|[2]Zimmerman CN, et al. Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia. Front Syst Neurosci. 2017 Jun 13;11:43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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