Dehydrofalcarinol

Dehydrofalcarinol is a polyacetylene compound found in Desmanthodium guatemalense. Dehydrofalcarinol shows potent inhibitory activity against MDA-MB-231, MDA-MB-157, BT-549, HCC1806, MDA-MB-468 and MDA-MB-453 cells with IC50 values of 0.051, 0.059, 0.22, 0.3, 0.85 and 2.8 μM. Dehydrofalcarinol shows anticancer activity depending on 17β-hydroxysteroid dehydrogenase (17β-HSD) type 11. Dehydrofalcarinol can be used for the research of triple-negative breast cancer[1].

Product Specifications

CAS Number

[36150-08-0]

UNSPSC

12352211

Target

17β-HSD

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

C=CCCCCC/C=C\CC#CC#C[C@H](O)C=C

Molecular Formula

C17H22O

Molecular Weight

242.36

References & Citations

[1]Grant CV, et al. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. J Nat Prod. 2020 Oct 23;83 (10) :3080-3092.