Piroctone

Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candida albicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research[1][2].

Product Specifications

CAS Number

[50650-76-5]

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Field of Research

Cancer; Infection

Smiles

O=C1C=C(C)C=C(CC(CC(C)(C)C)C)N1O

Molecular Formula

C14H23NO2

Molecular Weight

237.34

References & Citations

[1]Sigle HC, et al. In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses. 2006 May;49 (3) :159-68.|[2]Sidarovich V, et al. Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells. Mol Pharmacol. 2015;87 (3) :513-24.