19-Nor-22-oxa-1a,25 (OH) 2-VD3
19-Nor-22-oxa-1a,25 (OH) 2-VD3 is a vitamin D₃ analogue. 19-Nor-22-oxa-1a,25 (OH) 2-VD3 has an extremely low affinity for the vitamin D receptor (VDR) and hardly binds to the vitamin D binding protein (DBP) . 19-Nor-22-oxa-1a,25 (OH) 2-VD3 can effectively induce the differentiation of HL-60 cells and cause G₀-G₁ phase cell cycle arrest. 19-Nor-22-oxa-1a,25 (OH) 2-VD3 can be used to study diseases such as excessive hyperparathyroidism[1].
Product Specifications
CAS Number
284041-36-7
UNSPSC
12352005
Target
VD/VDR
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)OCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C[C@@H](C\3)O)O
Molecular Formula
C25H42O4
Molecular Weight
406.60
References & Citations
[1]Kubodera NK, et al. Biological activities of 19-nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring. Curr Pharm Des. 2000 May;6 (7) :791-801.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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