NSC 104999
NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (Kd = 32.3 μM) . NSC 104999 exhibits anticancer activity against breast cancer[1].
Product Specifications
CAS Number
[1118745-14-4]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C(NC2=CC(C3=NCCN3)=CC(C(NCCCC)=O)=C2)=O)C=C1)NC4=CC(C5=NCCN5)=CC(C(NCCCC)=O)=C4
Molecular Formula
C36H42N8O4
Molecular Weight
650.77
References & Citations
[1]Ambaye ND, et al. The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents. ChemMedChem. 2013 Feb;8 (2) :280-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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