N-Desmethyl clindamycin (hydrochloride)
N-Desmethyl clindamycin hydrochloride is the main metabolite of Clindamycin (HY-B1455) . N-Desmethyl clindamycin hydrochloride shows potent cytotoxicity against L1210, KB, RPMI 6410 and RPMI 1788 cancer cells with LD50 values of 0.07, 0.29, 0.13 and 0.32 μM. N-Desmethyl clindamycin hydrochloride can inhibit cell DNA, RNA and protein synthesis. N-Desmethyl clindamycin hydrochloride can be used for the research of infection and cancer[1].
Product Specifications
CAS Number
[25532-03-0]
UNSPSC
12352005
Target
DNA/RNA Synthesis; Drug Metabolite
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Smiles
O=C([C@@H]1C[C@H](CN1)CCC)N[C@@H]([C@]2([H])[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](Cl)C.Cl
Molecular Formula
C17H32Cl2N2O5S
Molecular Weight
447.42
References & Citations
[1]Li L H, et al. Cytotoxicity of several marketed antibiotics on mammalian cells in culture[J]. The Journal of Antibiotics, 1977, 30 (6) : 506-512.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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