TCCNeu5Ac

TCCNeu5Ac (compound H-56) is a high-affinity and selective trisaccharide glycan ligand for Siglec-1 (CD169) [1][2]. TCCNeu5Ac azide can be conjugated to lipids to selectively target cells expressing either murine or human CD169 in vitro, exhibiting in vivo targeting to CD169-positive macrophages. TCCNeu5Ac can be used for in vivo macrophage delivery[3].

Product Specifications

CAS Number

[3036471-42-5]

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Others

Smiles

OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CNC(C2=CC(COC3=CC=CC=C34)=C4S2)=O)O[C@@H]5[C@H]([C@@H](O[C@@H]([C@@H]5O)CO)O[C@@H]6[C@H](O[C@H]([C@@H]([C@H]6O)NC(C)=O)OCCN=[N+]=[N-])CO[Na])O)=O

Molecular Formula

C39H51N6NaO20S

Molecular Weight

978.91

References & Citations

[1]Namita BISARIA, et al. Glycan conjugate compositions and methods. WO2024086767. 2024-04-25.|[2]Xu Yan, et al. A kind of affine three sugar compounds of CD169 and preparation method thereof. CN110041381. 2019-07-23.|[3]Nycholat CM, et al. In silico-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J Am Chem Soc. 2012 Sep 26;134 (38) :15696-9.